The 49ers defense is described as "elite" and has been dominating opponents since the Bye week.
Despite their strong defense, some offenses, like Seattle with backup quarterback Drew Lock, have caused challenges.
The upcoming game presents a tough matchup as the 49ers face the Cardinals and quarterback Kyler Murray.
Kyler Murray, who has been solid since returning from injury, poses a significant challenge for the 49ers defense.
Historically, Murray has given the 49ers more trouble than other NFC West quarterbacks, even surpassing Russell Wilson.
The Cardinals, coming off a Bye week, will be rested and well-prepared, making the matchup even more challenging.
The defensive coordinator, Steve Wilks, emphasizes the importance of being sound in defensive responsibilities against Murray's zone-read.
Murray's ability to scramble and make plays adds complexity to defending against him, requiring containment strategies.